FIGURE 1: Deregulation of endogenous glucose production leads to hepatic complications. In normal physiological conditions, the liver maintains glucose homeostasis in the blood by releasing free glucose during fasts and by up-taking and storing excessive glucose during post-prandial periods. In type 2 diabetes, hepatic production and uptake of glucose is deregulated, resulting in hyperglycemia. In Glycogen Storage Disease type I (GSDI), glucose production in completely abolished, resulting in hypoglycemia. Strikingly, both of these pathologies are characterized by non-alcoholic fatty liver disease (NAFLD) development that can lead to hepatocellular carcinoma in some cases.