Back to article: Mitochondrial stress delays tumorigenesis in a Li-Fraumeni syndrome mouse model
FIGURE 1: Proposed anti-proliferative signaling mechanism in response to mitochondrial inhibition. Inhibition of mitochondrial respiration genetically (Polgmut/mut) or pharmacologically (metformin) can delay tumorigenesis in association with induction of autophagy and GSK3-mediated suppression of cyclin D1 to affect cell cycle progression.