Back to article: p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway


FIGURE 3: Reduction of PDCD4 is caused by p38-stimulated pro-teasome degradation. (A) Tsc1+/+ and Tsc1-/- fibroblasts were serum-starved overnight prior to treat-ment with the indicated inhibitors for 90 minutes and subsequent Aniso stimulation for 4 hours. (B) BMDMs were treated with MG-132, LPS or cycloheximide (Chx) as indi-cated for 4 hours. Immunoblots were analyzed as depicted.

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