Back to article: T lymphocytes against solid malignancies: winning ways to defeat tumours


TABLE 2. Factors regulating CD8+ TIL functionality inside the TME. List of molecules that can inhibit, or sustain, tumour-infiltrating-T-lymphocyte (TIL) functionality inside the tumour microenvironment. The corresponding receptors on TIL surface of the indicated check-point molecules are reported in brackets.

Abbreviations: TILs: tumor-infiltrating-T-lymphocytes; IDO: Indoleamine-2,3-dioxygenase; COX2: cyclo-oxigenase2; PGE2: Prostaglandin E2.

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