FIGURE 1: Imprint on NK cell diversity by chronic HCV infec-tion. Schematic illustration on how chronic HCV infection affects NK cell inter-individual variability evaluated determining donor-to-donor expression variation (DEV) (top left panel). Assessment of intra-individual diversity within the NK cell population using the Simpson diversity index (SDI) in healthy controls and patients with chronic HCV (top right panel). Longitudinal characterization of DEV and SDI in chronic HCV infection, before, during, and after viral clearance using direct-acting antivirals (DAA) (lower panel).