FIGURE 2: Roles of Snap29 in endocytosis and recycling. Snap29 is required for internalization of the IGF-1R receptor (A), for internalization and/or recycling of TFR (B) and for formation of the basal membrane surrounding the cilium microtubules (light blue; C). All these functions are regulated in association with the endocytic factor EHD1, which binds the NPF motif of Snap29 (see text for details).